Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin
Identifieur interne : 001646 ( Main/Exploration ); précédent : 001645; suivant : 001647Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin
Auteurs : Bartholomew O. Ibeh [Nigeria] ; Onyechi Obidoa [Nigeria] ; Chinedu Nwuke [Nigeria]Source :
- Indian Journal of Clinical Biochemistry [ 0970-1915 ] ; 2011-07-01.
Descripteurs français
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
Abstract
Abstract: We recruited 59 individuals of known HIV serostatus after informed consent however, 44 were serodiscordant heterosexual partners [serodiscordant seronegative (SSN group) and serodiscordant seropositive (SSP group)] while 15 were seronegative healthy individuals (SNH). In the case–control study we choose to determine Malondialdehyde (MDA) concentration as a marker of lipid peroxidation index (oxidative stress) spectrophotometrically and quantify HIV mRNA by Real Time-nucleic acid sequence based amplification assay (RT-NASBA). Here our result show for the first time a high concentration of lipid peroxidation product (MDA, 116.6%) with a significant (P < 0.05) increase in HIV serodiscordant seropositive subjects over their seronegative partners. However, Spearman rank correlation statistics of SSP group showed a positive correlation value (P < 0.01, r = 0.89) between MDA and mRNA and a negative correlation between MDA and T-cell ratio (P < 0.01, r = 0.96).The study may strongly indicate a possible lipid peroxidation product threshold for predicting HIV infection and progression in serodiscordant heterosexual partners.
Url:
DOI: 10.1007/s12291-011-0120-8
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000458
- to stream Istex, to step Curation: 000458
- to stream Istex, to step Checkpoint: 000613
- to stream Main, to step Merge: 001648
- to stream Main, to step Curation: 001646
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin</title><author><name sortKey="Ibeh, Bartholomew O" sort="Ibeh, Bartholomew O" uniqKey="Ibeh B" first="Bartholomew O." last="Ibeh">Bartholomew O. Ibeh</name></author><author><name sortKey="Obidoa, Onyechi" sort="Obidoa, Onyechi" uniqKey="Obidoa O" first="Onyechi" last="Obidoa">Onyechi Obidoa</name></author><author><name sortKey="Nwuke, Chinedu" sort="Nwuke, Chinedu" uniqKey="Nwuke C" first="Chinedu" last="Nwuke">Chinedu Nwuke</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D493FCF04C211B7AF4D17451BC5ED012BC967C1B</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s12291-011-0120-8</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-W63GRM9S-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000458</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000458</idno><idno type="wicri:Area/Istex/Curation">000458</idno><idno type="wicri:Area/Istex/Checkpoint">000613</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000613</idno><idno type="wicri:doubleKey">0970-1915:2011:Ibeh B:lipid:peroxidation:correlates</idno><idno type="wicri:Area/Main/Merge">001648</idno><idno type="wicri:Area/Main/Curation">001646</idno><idno type="wicri:Area/Main/Exploration">001646</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin</title><author><name sortKey="Ibeh, Bartholomew O" sort="Ibeh, Bartholomew O" uniqKey="Ibeh B" first="Bartholomew O." last="Ibeh">Bartholomew O. Ibeh</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, University of Nigeria, Nsukka</wicri:regionArea><wicri:noRegion>Nsukka</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267, Umuahia, Abia State</wicri:regionArea><wicri:noRegion>Abia State</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Nigeria</country></affiliation></author><author><name sortKey="Obidoa, Onyechi" sort="Obidoa, Onyechi" uniqKey="Obidoa O" first="Onyechi" last="Obidoa">Onyechi Obidoa</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, University of Nigeria, Nsukka</wicri:regionArea><wicri:noRegion>Nsukka</wicri:noRegion></affiliation></author><author><name sortKey="Nwuke, Chinedu" sort="Nwuke, Chinedu" uniqKey="Nwuke C" first="Chinedu" last="Nwuke">Chinedu Nwuke</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>R & D Department, Shell Petroleum, PortHarcourt</wicri:regionArea><wicri:noRegion>PortHarcourt</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Indian Journal of Clinical Biochemistry</title><title level="j" type="abbrev">Ind J Clin Biochem</title><idno type="ISSN">0970-1915</idno><idno type="eISSN">0974-0422</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>India</pubPlace><date type="published" when="2011-07-01">2011-07-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="249">249</biblScope><biblScope unit="page" to="256">256</biblScope></imprint><idno type="ISSN">0970-1915</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0970-1915</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HIV/AIDS</term><term>MDA</term><term>Nigeria</term><term>Oxidative stress</term><term>Serodiscordant</term><term>mRNA</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We recruited 59 individuals of known HIV serostatus after informed consent however, 44 were serodiscordant heterosexual partners [serodiscordant seronegative (SSN group) and serodiscordant seropositive (SSP group)] while 15 were seronegative healthy individuals (SNH). In the case–control study we choose to determine Malondialdehyde (MDA) concentration as a marker of lipid peroxidation index (oxidative stress) spectrophotometrically and quantify HIV mRNA by Real Time-nucleic acid sequence based amplification assay (RT-NASBA). Here our result show for the first time a high concentration of lipid peroxidation product (MDA, 116.6%) with a significant (P < 0.05) increase in HIV serodiscordant seropositive subjects over their seronegative partners. However, Spearman rank correlation statistics of SSP group showed a positive correlation value (P < 0.01, r = 0.89) between MDA and mRNA and a negative correlation between MDA and T-cell ratio (P < 0.01, r = 0.96).The study may strongly indicate a possible lipid peroxidation product threshold for predicting HIV infection and progression in serodiscordant heterosexual partners.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Ibeh, Bartholomew O" sort="Ibeh, Bartholomew O" uniqKey="Ibeh B" first="Bartholomew O." last="Ibeh">Bartholomew O. Ibeh</name></noRegion><name sortKey="Ibeh, Bartholomew O" sort="Ibeh, Bartholomew O" uniqKey="Ibeh B" first="Bartholomew O." last="Ibeh">Bartholomew O. Ibeh</name><name sortKey="Ibeh, Bartholomew O" sort="Ibeh, Bartholomew O" uniqKey="Ibeh B" first="Bartholomew O." last="Ibeh">Bartholomew O. Ibeh</name><name sortKey="Nwuke, Chinedu" sort="Nwuke, Chinedu" uniqKey="Nwuke C" first="Chinedu" last="Nwuke">Chinedu Nwuke</name><name sortKey="Obidoa, Onyechi" sort="Obidoa, Onyechi" uniqKey="Obidoa O" first="Onyechi" last="Obidoa">Onyechi Obidoa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001646 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001646 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D493FCF04C211B7AF4D17451BC5ED012BC967C1B
|texte= Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin
}}
| This area was generated with Dilib version V0.6.33. |  |